[Neutron] Postdoc position on transthyretin amyloidosis

[Trevor Forsyth]

Postdoctoral researcher on transthyretin amyloidosis at Lund University Medical Faculty



31st March 2024.


A highly motivated postdoctoral researcher is sought to work on the molecular mechanisms underlying amyloid formation and associated assembly processes. The work will be based in the Molecular Biophysics Group within the Biomedical Center (BMC) at the Faculty of Medicine at Lund University, led by Professor Trevor Forsyth.  The major focus of the work will be transthyretin amyloidosis (see https://www.nature.com/articles/s41467-019-08609-z/ ).  Human transthyretin (TTR) is a protein that transports thyroxine and retinol-binding protein (RBP) in the serum and cerebrospinal fluid. Wild-type TTR is intrinsically amyloidogenic, but a large number of TTR mutants have been identified, having remarkable tissue specificities.  This project seeks to deepen molecular-level understanding of amyloidosis as well as undertaking detailed comparative studies of amyloid material derived from in vitro and ex vivo sources. It will make extensive use of X-ray and neutron diffraction, cryo-EM, and a wide range of other biophysical techniques. It will make use of the MAX-IV facility in Sweden as well as the ESRF and ILL X-ray/neutron sources in Grenoble, France. The project will have good access to state-of-the-art facilities within the medical, natural science and engineering faculties, as well as being located in close proximity to MAX-IV and ESS, the Science Village located between them, and the LINXS advanced study institute (https://www.linxs.se/).

To apply for this position, see https://www.ambercofund.eu/for-applicants. Informal enquiries to Trevor Forsyth (trevor.forsyth at med.lu.se<mailto:trevor.forsyth at med.lu.se>).

This position is funded under the  EU MCSA COFUND project on Advanced Multiscale Biological imaging using European Research infrastructures (AMBER). To read more about AMBER see https://www.ambercofund.eu. The AMBER partner organisations are Lund University, the MAX IV synchrotron radiation source, Sweden, the European Molecular Biology Laboratory (EMBL), the Institut Laue-Langevin (ILL), France, the European Spallation Source (ESS), Sweden, the International Institute of Molecular Mechanisms and Machines, (IMOL), Poland, and the Leicester Institute of Structural and Chemical Biology, UK. AMBER is coordinated by LINXS.

Link to the AMBER Linkedin: https://www.linkedin.com/company/amber-postdoctoral-programme

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