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<p class="MsoNormal">A postdoc position is available at the NIST Center for Neutron Research in Gaithersburg (NCNR), Maryland. NIST (National Institute of Standards and Technology) is a scientific research laboratory of Department of Commerce. This project
is a collaborative effort between NCNR and a major pharmaceutic company. <br>
<br>
We are looking for a highly motivated postdoctoral scientist to join us to study protein-protein and protein-excipient interactions in concentrated protein formulations using scattering techniques. The postdoc is expected to work closely with industrial scientists
in a major pharmaceutic company as well as collaborate with scientists on NIST campus.
<br>
<br>
Project Description: <br>
<br>
There is an urgent need to understand protein-protein and protein-excipient behavior in high-concentration formulations sought in many pharmaceutic products. X-ray and neutron scattering have been traditionally used to look at long- and short-ranged interactions
in a variety of polymer and protein systems. Because the interaction between monoclonal antibodies (mAbs) is intrinsically anisotropic, the understanding of the anisotropic protein-protein interaction is critical to accurately predict the properties of concentrated
mAb solutions. By closely working with industrial scientists, this project aims to develop methods aided by computer simulations to extract the anisotropic interaction between proteins. Combining the theoretical development, experimental efforts using SANS
and SAXS, and computer simulation, we aim to significantly improve the accuracy of extracting anisotropic protein-protein interaction potential information from mAb-based therapeutic solutions using SAXS or SANS.<br>
<br>
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<p class="MsoNormal">Qualifications:<o:p></o:p></p>
<p class="MsoNormal">Candidates need to have a Ph.D. in Chemical Engineering, Materials Science, Physics, or other equivalent education background with a research focus on soft matter materials. A background in neutron or x-ray scattering techniques is beneficial,
but not essential. Initial appointment will be for one year, with renewal up to two years subject to both satisfactory progress and the availability of funds. The position is open for US citizen only. The starting date is negotiable.<o:p></o:p></p>
<p class="MsoNormal"><br>
Contacts:<br>
If interested, please feel free to contact Dr. Yun Liu (<a href="mailto:yun.liu@nist.gov">yun.liu@nist.gov</a> ), Dr. Vincent Shen (<a href="mailto:Vincent.shen@nist.gov">Vincent.shen@nist.gov</a> ), Dr. Wick Hatch (<a href="mailto:harold.hatch@nist.gov">harold.hatch@nist.gov</a>
) or Dr. Alexander Grishaev (<a href="mailto:alexander.grishaev@nist.gov">alexander.grishaev@nist.gov</a> ).<o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:9.0pt">**********************************<br>
Yun Liu, Ph.D.<br>
<br>
Affiliated Professor<br>
Department of Chemical &Biomolecular Engineering<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt">Department of Physics & Astronomy<br>
University of Delaware<br>
<br>
Instrument Scientist<br>
NIST Center for Neutron Research<br>
<br>
100 Bureau Drive MS 6102<br>
Gaithersburg, MD 20899-6102, USA<br>
Room E127, Building 235<br>
Voice +1 301 975 6235<br>
Fax +1 301 921 9847<br>
URL: <a href="https://www.nist.gov/people/yun-liu"><span style="color:blue">https://www.nist.gov/people/yun-liu</span></a><br>
***********************************<o:p></o:p></span></p>
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