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<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Dear Colleagues,<span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">I would like to invite you to contribute to a Special Issue on “Biological
Small Angle Scattering: Techniques and Applications” in the Journal <em><span style="font-family:"Calibri",sans-serif">Applied Sciences.</span></em><span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Small angle scattering (SAS) in either X-ray or Neutron (SAXS/SANS) has
become an essential technique in understanding biological structures and
processes. The technique is amenable to samples in solution without
crystallization and cryogenic preparation, providing an opportunity to study
biomolecules in a more physiologically relevant condition. For example, the
ensemble of structural conformations from SAS provides a critical understanding
of large flexible and disordered systems. The contrast manipulation by SANS and
deuterium labeling provides a viable approach to understand subunit structure
in the context of the whole complex.<span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">In this Special Issue, we invite <b>original articles, review articles, and
case reports highlighting new developments of the technique and their
applications to explore new aspects of biological systems</b>. Those include
but are <b>not limited to new instrumentation, sample preparation, sample
environment, data process, and analysis methods/software.<span></span></b></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span class="gmail-si-deadline">Deadline for manuscript submissions: <b>10 October
2021</b></span>. <span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Please let me know if you have any question. <a href="mailto:qians@ornl.gov" style="color:rgb(5,99,193);text-decoration:underline">qians@ornl.gov</a><span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Best regards,<span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Dr. Shuo Qian<br>
<em><span style="font-family:"Calibri",sans-serif">Guest Editor</span></em><span></span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><b><span style="font-size:18pt">Keywords<span></span></span></b></p>

<ul style="margin-bottom:0in" type="disc"><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>small angle scattering<span></span></span></li><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>SAXS<span></span></span></li><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>SANS<span></span></span></li><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>biological SAS<span></span></span></li><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>solution SAS<span></span></span></li><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>protein structure<span></span></span></li><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>membrane structure<span></span></span></li><li class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span>biomolecule structure<span></span></span></li></ul>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span> </span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif"><strong><span style="font-family:"Calibri",sans-serif">Manuscript Submission
Information</span></strong><span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Manuscripts should be submitted online at <a href="https://www.mdpi.com/" style="color:rgb(5,99,193);text-decoration:underline">www.mdpi.com</a>
by <a href="https://www.mdpi.com/user/register/" style="color:rgb(5,99,193);text-decoration:underline">registering</a> and <a href="https://www.mdpi.com/user/login/" style="color:rgb(5,99,193);text-decoration:underline">logging in to this website</a>. Once
you are registered, <a href="https://susy.mdpi.com/user/manuscripts/upload/?journal=applsci" style="color:rgb(5,99,193);text-decoration:underline">click
here to go to the submission form</a>. Manuscripts can be submitted until the
deadline. All papers will be peer-reviewed. Accepted papers will be published
continuously in the journal (as soon as accepted) and will be listed together
on the special issue website. Research articles, review articles as well as
short communications are invited. For planned papers, a title and short
abstract (about 100 words) can be sent to the Editorial Office for announcement
on this website.<span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Submitted manuscripts should not have been published previously, nor be under
consideration for publication elsewhere (except conference proceedings papers).
All manuscripts are thoroughly refereed through a single-blind peer-review
process. A guide for authors and other relevant information for submission of
manuscripts is available on the <a href="https://www.mdpi.com/journal/applsci/instructions" style="color:rgb(5,99,193);text-decoration:underline">Instructions for
Authors</a> page. <a href="https://www.mdpi.com/journal/applsci/" style="color:rgb(5,99,193);text-decoration:underline"><em><span style="font-family:"Calibri",sans-serif;color:blue">Applied Sciences</span></em></a>
is an international peer-reviewed open access semimonthly journal published by
MDPI.<span></span></p>

<p style="margin-right:0in;margin-left:0in;font-size:11pt;font-family:"Calibri",sans-serif">Please visit the <a href="https://www.mdpi.com/journal/applsci/instructions" style="color:rgb(5,99,193);text-decoration:underline">Instructions
for Authors</a> page before submitting a manuscript. The <a href="https://www.mdpi.com/about/apc/" style="color:rgb(5,99,193);text-decoration:underline">Article Processing Charge (APC)</a> for
publication in this <a href="https://www.mdpi.com/about/openaccess/" style="color:rgb(5,99,193);text-decoration:underline">open
access</a> journal is 2000 CHF (Swiss Francs). Submitted papers should be well
formatted and use good English. Authors may use MDPI's <a href="https://www.mdpi.com/authors/english" style="color:rgb(5,99,193);text-decoration:underline">English editing service</a> prior
to publication or during author revisions. <span></span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span> </span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span style="font-size:10pt">~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<br>
Shuo Qian, Ph.D.<br>
Staff Scientist<br>
Center for Structural Molecular Biology<span></span></span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span style="font-size:10pt">Large Scale Structures Group<br>
Neutron Scattering Division<span></span></span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span style="font-size:10pt">&<span></span></span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span style="font-size:10pt">Second Target Station Project<br>
Oak Ridge National Laboratory<span></span></span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span style="font-size:10pt"><a href="http://neutrons.ornl.gov/contacts/qians" style="color:rgb(5,99,193);text-decoration:underline">http://neutrons.ornl.gov/contacts/qians</a><br>
Postal Address:<br>
PO BOX 2008 MS6393<br>
OAK RIDGE TN 37831-6430<br>
Email:  <a href="mailto:qians@ornl.gov" style="color:rgb(5,99,193);text-decoration:underline"><span style="color:blue">qians@ornl.gov</span></a><br>
Phone: <a href="tel:865-241-1934" style="color:rgb(5,99,193);text-decoration:underline"><span style="color:blue">865-241-1934</span></a><br>
Fax:      <a href="tel:865-241-6770" style="color:rgb(5,99,193);text-decoration:underline"><span style="color:blue">865-241-6770</span></a><span></span></span></p>

<p class="MsoNormal" style="margin:0in;font-size:11pt;font-family:"Calibri",sans-serif"><span> </span></p>





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