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<p class="MsoPlainText"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Postdoctoral researcher on transthyretin amyloidosis at Lund University Medical Faculty<o:p></o:p></span></b></p>
<p class="MsoPlainText"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif">A highly motivated postdoctoral researcher is sought to work on the molecular mechanisms underlying amyloid formation
and associated assembly processes. The work will be based in the Molecular Biophysics Group within the Biomedical Center (BMC) at the Faculty of Medicine at Lund University, led by Professor Trevor Forsyth. The major focus of the work will be transthyretin
amyloidosis (see <a href="https://www.nature.com/articles/s41467-019-08609-z/">https://www.nature.com/articles/s41467-019-08609-z/</a> ).
</span></span><span class="q4iawc"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Arial",sans-serif">Human transthyretin (TTR) is protein that transports thyroxine and retinol-binding protein (RBP) in the serum and cerebrospinal fluid. Wild-type TTR
is intrinsically amyloidogenic, but a large number of TTR mutants have been identified, having remarkable tissue specificities. This project seeks to deepen molecular-level understanding of amyloidosis as well as undertaking detailed comparative studies of
amyloid material derived from <i>in vitro</i> and <i>ex vivo </i>sources. It will make extensive use of X-ray and neutron diffraction, cryo-EM, and a wide range of other biophysical techniques. It will make use of the MAX-IV facility in Sweden as well as the
ESRF and ILL X-ray/neutron sources in Grenoble, France. </span></span><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif">The project
</span></span><span class="q4iawc"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Arial",sans-serif">will have</span></span><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif"> good access to state-of-the-art
facilities within the medical, natural science and engineering faculties, as well as being located in close proximity to MAX-IV and ESS, the Science Village located between them, and the LINXS advanced study institute (<a href="https://www.linxs.se/">https://www.linxs.se/</a>).
</span></span><span class="q4iawc"><span lang="EN-GB"><o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></span></p>
<p class="MsoPlainText"><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif">The desired start date is February 1<sup>st</sup> 2023 or by agreement.<o:p></o:p></span></span></p>
<p class="MsoPlainText"><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">To apply for the position, please go to
<a href="https://lu.varbi.com/en/what:job/jobID:557181/">https://lu.varbi.com/en/what:job/jobID:557181/</a>
</span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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