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<!--StartFragment--><p class="MsoNormal" style="text-align:justify"><b class=""><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">Context and Job Description:<o:p class=""></o:p></span></b></p><p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">A PhD position co-financed by
Université Grenoble Alpes (UGA) and the Institut Laue-Langevin (ILL) is
available on the following subject:</span><span style="font-size: 11pt;" class=""> </span></p><p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">"<i class="">Conformation and
function of proteins at homogeneous and nanostructured interfaces</i>"</span><span style="font-size: 11pt;" class=""> </span></p><p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">The immobilisation of proteins
at interfaces is important to many medical, biomedical and biotechnological
applications. However, the interaction of the proteins with the immobilising
interface can have a detrimental effect on their activity, due to the
surface-induced changes in their structure and mobility.</span></p><p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">By combining different
lab-based techniques such as electrical impedance spectroscopy, quartz crystal microbalance,
microscopy, with equipment from large scale facilities (Neutron and X-ray
Reflectometry, Small Angle Neutron and X-ray Scattering), we plan to study the
effect of the immobilization of a particular membrane protein, the sodium-hydrogen
exchanger NhaA, which has relevant biotechnological applications.</span></p><p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">The PhD student will be hosted
in the TIMC laboratory (UGA) and at the Institut-Laue Langevin and jointly
supervised by Dr. M. Maccarini (SyNaBi group at TIMC), Prof. D. Martin (SyNaBi
group at TIMC) and Dr Ben Humphreys (ILL).</span></p><p class="MsoNormal" style="text-align:justify"><b class=""><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">SyNaBi group at TIMC
laboratory </span></b><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:
EN-US" class="">is a dynamic research team with a focussed thematic axis in biological
engineering.<b class=""> </b>Our primary objective is to conduct fundamental
research to investigate the role of biological molecules (e.g., enzymes,
proteins) in various applications, including lipid bilayers, biosensors,
biomimetic cell systems, and drug delivery systems. Our research endeavours
span from the nanoscale to the microscale and macroscale, enabling us to gain
comprehensive insights into these complex systems. To achieve this
multidimensional exploration, the SyNaBi team harnesses its core expertise in
electrophysiology, biophysics, large-scale facililities (neutron and X-ray
scattering), bioelectrochemistry, opto-acoustic intravital microscopy,
biopolymers, drug delivery, and cell/molecular biology.</span></p><p class="MsoNormal" style="text-align:justify"><b class=""><span style="font-size:11.0pt" class="">The
Institut Laue-Langevin</span></b><span style="font-size:11.0pt" class=""> is an
international research centre at the leading edge of neutron science and
technology.</span><span style="font-size:11.0pt;mso-ansi-language:EN-US" class=""> </span><span style="font-size:11.0pt" class="">As the world’s flagship centre for neutron science,
the ILL provides scientists with a very high flux of neutrons feeding some 40
state-of-the-art instruments, which are constantly being developed and
upgraded.</span></p><p class="MsoNormal" style="text-align:justify"><b class=""><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">Expected profile and skills:<o:p class=""></o:p></span></b></p><p class="MsoListParagraphCxSpFirst" style="text-align:justify;text-indent:-18.0pt;
mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;background:white"><!--[if !supportLists]--><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size:11.0pt;font-family:Symbol;
mso-fareast-font-family:Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:
EN-US" class="">·<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class="">
</span></span><!--[endif]--><span lang="EN-US" style="font-size: 11pt;" class="">Degree allowing
enrolment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent)
in physics, materials science, chemistry or closely related science</span><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class=""><o:p class=""></o:p></span></p><p class="MsoListParagraphCxSpMiddle" style="text-align:justify;text-indent:-18.0pt;
mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;background:white"><!--[if !supportLists]--><span style="font-size:10.0pt;mso-bidi-font-size:11.0pt;font-family:Symbol;
mso-fareast-font-family:Symbol;mso-bidi-font-family:Symbol;color:#585858;
mso-color-alt:windowtext" class="">·<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class=""> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 11pt;" class="">The candidate should be able to work in a highly
interdisciplinary environment.</span><span style="font-size:11.0pt;font-family:
"Open Sans",sans-serif;color:#585858" class=""><o:p class=""></o:p></span></p><p class="MsoListParagraphCxSpMiddle" style="text-align:justify;text-indent:-18.0pt;
mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;background:white"><!--[if !supportLists]--><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size:11.0pt;font-family:Symbol;
mso-fareast-font-family:Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:
EN-US" class="">·<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class="">
</span></span><!--[endif]--><span lang="EN-US" style="font-size: 11pt;" class="">background in
large scale facilities experiments (neutron and x-ray scattering), and
knowledge computer programming (C++, Python) would be an advantage</span><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class=""><o:p class=""></o:p></span></p><p class="MsoListParagraphCxSpLast" style="text-align:justify;text-indent:-18.0pt;
mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;background:white"><!--[if !supportLists]--><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size:11.0pt;font-family:Symbol;
mso-fareast-font-family:Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:
EN-US" class="">·<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class="">
</span></span><!--[endif]--><span lang="EN-US" style="font-size: 11pt;" class="">Ability in
handling of biological materials would be an advantage</span></p><p class="MsoNormal" style="text-align:justify"><b class=""><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">Working Conditions<o:p class=""></o:p></span></b></p><p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt" class="">The
successful candidate will be enrolled </span><span lang="EN-US" style="font-size:
11.0pt;mso-ansi-language:EN-US" class="">full-time in</span><span lang="EN-US" style="font-size:11.0pt" class=""> </span><span style="font-size:11.0pt" class="">the doctoral
school of </span><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:
EN-US" class="">UGA</span><span style="font-size:11.0pt" class=""> and based 50% at the ILL
(Grenoble, France</span><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:
EN-US" class="">) </span><span style="font-size:11.0pt" class="">and 50% at TIMC. Furthermore, a
varied pedagogical training programme will be offered to the successful
candidate throughout the 3-year PhD project.</span></p><p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US" class="">Questions can be addressed to <a href="mailto:marco.maccarini@univ-grenoble-alpes.fr" class="">marco.maccarini@univ-grenoble-alpes.fr</a>,
<a href="mailto:donald.martin@univ-grenoble-alpes.fr" class="">donald.martin@univ-grenoble-alpes.fr</a>, or <a href="mailto:humphreys@ill.fr" class="">humphreys@ill.fr</a></span><o:p class=""></o:p></p>
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