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<p class="MsoPlainText"><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Arial",sans-serif">Postdoctoral researcher on transthyretin amyloidosis at Lund University Medical Faculty<o:p></o:p></span></b></p>
<p class="MsoPlainText"><span lang="EN-US" style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif">A highly motivated postdoctoral researcher is sought to work on the molecular mechanisms underlying amyloid formation
and associated assembly processes. The work will be based in the Molecular Biophysics Group within the Biomedical Center (BMC) at the Faculty of Medicine at Lund University, led by Professor Trevor Forsyth. The major focus of the work will be transthyretin
amyloidosis (see <a href="https://www.nature.com/articles/s41467-019-08609-z/">https://www.nature.com/articles/s41467-019-08609-z/</a> ).
</span></span><span class="q4iawc"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Arial",sans-serif">Human transthyretin (TTR) is a protein that transports thyroxine and retinol-binding protein (RBP) in the serum and cerebrospinal fluid. Wild-type
TTR is intrinsically amyloidogenic, but a large number of TTR mutants have been identified, having remarkable tissue specificities. This project seeks to deepen molecular-level understanding of amyloidosis as well as undertaking detailed comparative studies
of amyloid material derived from <i>in vitro</i> and <i>ex vivo </i>sources. It will make extensive use of X-ray and neutron diffraction, cryo-EM, and a wide range of other biophysical techniques. It will make use of the MAX-IV facility in Sweden as well as
the ESRF and ILL X-ray/neutron sources in Grenoble, France. </span></span><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif">The project
</span></span><span class="q4iawc"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Arial",sans-serif">will have</span></span><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif"> good access to state-of-the-art
facilities within the medical, natural science and engineering faculties, as well as being located in close proximity to MAX-IV and ESS, the Science Village located between them, and the LINXS advanced study institute (<a href="https://www.linxs.se/">https://www.linxs.se/</a>).
</span></span><span class="q4iawc"><span lang="EN"><o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN-US" style="font-size:12.0pt;font-family:"Arial",sans-serif">To apply for this position, see
<a href="https://www.ambercofund.eu/for-applicants">https://www.ambercofund.eu/for-applicants</a>. Informal enquiries to Trevor Forsyth (<a href="mailto:trevor.forsyth@med.lu.se">trevor.forsyth@med.lu.se</a>).
</span></span><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN"><o:p> </o:p></span></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif">This position is funded under the EU MCSA COFUND project on Advanced Multiscale Biological imaging using European
Research infrastructures (AMBER). </span></span><span class="q4iawc"><span lang="EN-US" style="font-size:12.0pt;font-family:"Arial",sans-serif">To read more about AMBER see</span></span><span lang="EN-US">
</span><span class="q4iawc"><span lang="EN-US" style="font-size:12.0pt;font-family:"Arial",sans-serif"><a href="https://www.ambercofund.eu">https://www.ambercofund.eu</a>.
</span></span><span class="q4iawc"><span lang="EN" style="font-size:12.0pt;font-family:"Arial",sans-serif">The AMBER partner organisations are Lund University, the MAX IV synchrotron radiation source, Sweden, the European Molecular Biology Laboratory (EMBL),
the Institut Laue-Langevin (ILL), France, the European Spallation Source (ESS), Sweden, the International Institute of Molecular Mechanisms and Machines, (IMOL), Poland, and the Leicester Institute of Structural and Chemical Biology, UK. AMBER is coordinated
by LINXS.<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-autospace:none"><span class="q4iawc"><span lang="EN-US"><o:p> </o:p></span></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Aptos",sans-serif">Link to the AMBER Linkedin:
<a href="https://www.linkedin.com/company/amber-postdoctoral-programme">https://www.linkedin.com/company/amber-postdoctoral-programme</a></span><span style="font-family:"Aptos",sans-serif;mso-fareast-language:EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Aptos",sans-serif;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
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