[Neutron] PhD Research Fellowship in Biological Soft Matter - “Mechanism of Antimicrobial Peptides seen by Neutron Scattering”

[Ines Crespo]

(sending this announcement on behalf of Reidar Lund, University of Oslo)

Dear colleagues,


a PhD-position in biological soft matter is available in my group at the 
University of Oslo (three year contact). 
http://uio.easycruit.com/vacancy/1778869/64291?iso=no

I would greatly appreciate if you could  forward this information to 
potential candidates.

Best,

Reidar
_________


Antimicrobial peptides and peptoidomimetic compounds such as peptoids, 
are promising candidates to fight resistant bacteria. However, their 
mechanism is not understood in detail and issues such as toxicity and 
sensitivity towards proteolytic degradation limit their practical 
applications. The project aims to understand the fundamental biophysical 
mechanism of antimicrobial peptides and petidomimetics so as to be 
better able to modify and design new effective antimicrobial agents.

The candidate will perform systematic studies of the interactions 
between model biomembranes (liposomes, supported bilayers) and 
antimicrobial peptides and investigate their effect on structure, 
dynamics and transport using manly X-ray and neutron scattering 
techniques. The main methods will be small angle neutron/X-ray 
scattering (SAXS/SANS), neutron/X-ray reflectometry including advanced 
data modeling. Complementary techniques are mainly light scattering, 
single ion conductivity (BLM) and calorimetry.

The PhD work will be done in close collaboration with Roskilde 
University and University of Copenhagen who will design, synthesize and 
perform biological characterization of the antimicrobial compounds.


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Inês Crespo
Information Manager, NMI3, SINE2020, Neutronsources.org
Phone: +49 (0)89 289 14615
http://sine2020.eu/

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