[Neutron] Postdoctoral researcher on transthyretin amyloidosis at Lund University Medical Faculty
trevor.forsyth at med.lu.se
Thu Oct 27 11:37:47 CEST 2022
Postdoctoral researcher on transthyretin amyloidosis at Lund University Medical Faculty
A highly motivated postdoctoral researcher is sought to work on the molecular mechanisms underlying amyloid formation and associated assembly processes. The work will be based in the Molecular Biophysics Group within the Biomedical Center (BMC) at the Faculty of Medicine at Lund University, led by Professor Trevor Forsyth. The major focus of the work will be transthyretin amyloidosis (see https://www.nature.com/articles/s41467-019-08609-z/ ). Human transthyretin (TTR) is protein that transports thyroxine and retinol-binding protein (RBP) in the serum and cerebrospinal fluid. Wild-type TTR is intrinsically amyloidogenic, but a large number of TTR mutants have been identified, having remarkable tissue specificities. This project seeks to deepen molecular-level understanding of amyloidosis as well as undertaking detailed comparative studies of amyloid material derived from in vitro and ex vivo sources. It will make extensive use of X-ray and neutron diffraction, cryo-EM, and a wide range of other biophysical techniques. It will make use of the MAX-IV facility in Sweden as well as the ESRF and ILL X-ray/neutron sources in Grenoble, France. The project will have good access to state-of-the-art facilities within the medical, natural science and engineering faculties, as well as being located in close proximity to MAX-IV and ESS, the Science Village located between them, and the LINXS advanced study institute (https://www.linxs.se/).
The desired start date is February 1st 2023 or by agreement.
To apply for the position, please go to https://lu.varbi.com/en/what:job/jobID:557181/
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