[Neutron] A postdoc position at NCNR for a biopharmaceutical project

[Liu, Yun (Fed)]

A postdoc position is available at the NIST Center for Neutron Research in Gaithersburg (NCNR), Maryland. NIST (National Institute of Standards and Technology) is a scientific research laboratory of Department of Commerce. This project is a collaborative effort between NCNR and a major pharmaceutic company.

We are looking for a highly motivated postdoctoral scientist to join us to study protein-protein and protein-excipient interactions in concentrated protein formulations using scattering techniques. The postdoc is expected to work closely with industrial scientists in a major pharmaceutic company as well as collaborate with scientists on NIST campus.

Project Description:

There is an urgent need to understand protein-protein and protein-excipient behavior in high-concentration formulations sought in many pharmaceutic products. X-ray and neutron scattering have been traditionally used to look at long- and short-ranged interactions in a variety of polymer and protein systems. Because the interaction between monoclonal antibodies (mAbs) is intrinsically anisotropic, the understanding of the anisotropic protein-protein interaction is critical to accurately predict the properties of concentrated mAb solutions. By closely working with industrial scientists, this project aims to develop methods aided by computer simulations to extract the anisotropic interaction between proteins. Combining the theoretical development, experimental efforts using SANS and SAXS, and computer simulation, we aim to significantly improve the accuracy of extracting anisotropic protein-protein interaction potential information from mAb-based therapeutic solutions using SAXS or SANS.

Qualifications:
Candidates need to have a Ph.D. in Chemical Engineering, Materials Science, Physics, or other equivalent education background with a research focus on soft matter materials. A background in neutron or x-ray scattering techniques is beneficial, but not essential. Initial appointment will be for one year, with renewal up to two years subject to both satisfactory progress and the availability of funds. The position is open for US citizen only. The starting date is negotiable.

Contacts:
If interested, please feel free to contact Dr. Yun Liu (yun.liu at nist.gov<mailto:yun.liu at nist.gov> ), Dr. Vincent Shen (Vincent.shen at nist.gov<mailto:Vincent.shen at nist.gov> ), Dr. Wick Hatch (harold.hatch at nist.gov<mailto:harold.hatch at nist.gov> ) or Dr. Alexander Grishaev (alexander.grishaev at nist.gov<mailto:alexander.grishaev at nist.gov> ).

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Yun Liu, Ph.D.

Affiliated Professor
Department of Chemical &Biomolecular Engineering
Department of Physics & Astronomy
University of Delaware

Instrument Scientist
NIST Center for Neutron Research

100 Bureau Drive MS 6102
Gaithersburg, MD 20899-6102, USA
Room E127, Building 235
Voice +1 301 975 6235
Fax   +1 301 921 9847
URL: https://www.nist.gov/people/yun-liu
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